TCR signaling by conventional CD4 + T cells is required for optimal maintenance of peripheral regulatory T cell numbers
Author:
Affiliation:
1. Department of Pathology and Laboratory MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA19104USA
2. First Department of Internal MedicineKansai Medical UniversityMoriguchiOsakaJapan
Funder
National Blood Foundation, American Society of Hematology
National Institutes of Health awarded
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/iid3.100
Reference17 articles.
1. Immunologic self‐tolerance maintained by activated T cells expressing IL‐2 receptor alpha‐chains (CD25). Breakdown of a single mechanism of self‐tolerance causes various autoimmune diseases;Sakaguchi S.;J. Immunol,1995
2. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
3. Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
4. Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
5. Peripheral Expression of Self-MHC-II Influences the Reactivity and Self-Tolerance of Mature CD4+ T Cells
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