Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with <scp>HLA‐A</scp>*3303 and <scp>HLA‐DPB1</scp>*0501-Reference-Cited by-同舟云学术

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501

Published:2024-02-24 Issue:5 Volume:95 Page:901-906
ISSN:0364-5134
Container-title:Annals of Neurology
language:en
Short-container-title:Annals of Neurology

Author:

Shu Yaqing¹,Huang Renliang²,Li Qihui¹,Lu Yi³,Yin Junping⁴,Li Huilu¹,Lan Zhike⁵,Zheng Xiujun⁶,Ye Jinlong⁵,Long Youming⁷^ORCID,Wang Zhanhang⁵,Xiao Li¹,Zhou Qiaomiao²,Liu Xu⁸,Fu Ying⁹^ORCID,Chen Hao¹⁰,Chen Juanjuan¹¹,Zhou Yanxia¹²,Zhou Juan¹³,Zhang Liting¹⁴,Zhou Jing¹⁵,Jiang Ying¹,Peng Fuhua¹,Lu Zhengqi¹,Petersen Frank¹⁶,Qiu Wei¹^ORCID,Yu Xinhua²¹⁶^ORCID

Affiliation:

1. Department of Neurology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou China

2. Department of Genetics and Prenatal Diagnosis Hainan Women and Children's Medical Center Haikou Hainan China

3. Department of Neurology, The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen China

4. Institute of Molecular Medicine and Experimental Immunology, University of Bonn Bonn Germany

5. Department of Neurology GuangDong 999 Brain Hospital Guangzhou China

6. Department of Neurology Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat‐Sen University Shantou China

7. Department of Neurology, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University Guangzhou China

8. Department of Neurology, West China Hospital Sichuan University Chengdu China

9. Department of Neurology and Institute of Neurology The First Affiliated Hospital of Fujian Medical University Fuzhou China

10. Department of Neurology The First Affiliated Hospital Nanchang University Nanchang China

11. Department of Neurology Peking University Shenzhen Hospital Shenzhen China

12. Department of Neurology Shenzhen Second Peopleʼs Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center Shenzhen China

13. Department of Neurology Chenzhou First People's Hospital Chenzhou China

14. Department of Neurology Jiangxi Chest Hospital Jiangxi China

15. Department of Neurology Foshan First People's Hospital Foshan China

16. Division of Pulmonary Immune Diseases Priority Area Chronic Lung Diseases, Research Center Borstel Borstel Germany

Abstract

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32–3.06, p = 0.00072, padj. = 0.046) and HLA‐DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA‐A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non‐carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95:901–906

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.26899

Reference18 articles.

1. Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

2. Autoimmune glial fibrillary acidic protein astrocytopathy

3. Aetiology and pathogenesis of paraneoplastic autoimmune disorders

4. Antibody-Mediated Encephalitis

5. Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients