Affiliation:
1. Department of Neurology University of Michigan Ann Arbor MI
2. NeuroNetwork for Emerging Therapies University of Michigan Ann Arbor MI
3. Department of Neurosurgery University of Michigan Ann Arbor MI
Abstract
Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024;95:635–652
Funder
Centers for Disease Control and Prevention
National Institutes of Health
Cited by
8 articles.
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