Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor-Reference-Cited by-同舟云学术

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor

Published:2014-04-11 Issue:6 Volume:20 Page:415-420
ISSN:1075-2617
Container-title:Journal of Peptide Science
language:en
Short-container-title:J. Pept. Sci.

Author:

Fittler Heiko¹,Avrutina Olga¹,Empting Martin²,Kolmar Harald¹

Affiliation:

1. Clemens-Schöpf Institute of Organic Chemistry and Biochemistry; Technische Universität Darmstadt; Alarich-Weiss-Straße 4 64287 Darmstadt Germany

2. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS); Department Drug Design and Optimization; Campus C2.3 66123 Saarbrücken Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/psc.2629/fullpdf

Reference37 articles.

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2. HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease;Oberst;Am. J. Physiol. Cell Physiol.,2005

3. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity;Szabo;J. Biol. Chem.,2008

4. Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters;Oberst;Clin. Cancer Res.,2002

5. Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis;Seitz;Arterioscler. Thromb. Vasc. Biol.,2007

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