Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning

Author:

Fogli Iseppe Alex1,Ni Haibo1,Zhu Sicheng1,Zhang Xianwei1,Coppini Raffaele2,Yang Pei‐Chi3,Srivatsa Uma4,Clancy Colleen E.13,Edwards Andrew G.1,Morotti Stefano1,Grandi Eleonora1

Affiliation:

1. Department of Pharmacology University of California Davis California USA

2. Department of Neuroscience, Psychology, Drug Sciences and Child Health (NeuroFarBa) University of Florence Florence Italy

3. Department of Physiology and Membrane Biology University of California Davis California USA

4. Department of Internal Medicine University of California Davis California USA

Funder

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference50 articles.

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2. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology

3. A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

4. Guidance on S7B nonclinical evaluation of the potential for delayed ventricular repolarization (QT Interval Prolongation) by Human Pharmaceuticals;Food and Drug Administration International Conference on Harmonisation;Fed. Regist.,2005

5. Guidance on E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non‐antiarrhythmic drugs;Food and Drug Administration International Conference on Harmonisation;Notice. Fed. Regist.,2005

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