Affiliation:
1. Department of obstetrics‐gynecology Xinqiao Hospital, Army Medical University Chongqing China
2. Faculty of nursing Chongqing Medical and Pharmaceutical College Chongqing China
3. Department of General Surgery Xinqiao Hospital, Army Medical University Chongqing China
Abstract
AbstractThe soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) is an α/β hydrolase fold protein that is, widely distributed throughout the body. Recent studies have highlighted that sEH, in the metabolism of polyunsaturated fatty acids, plays a part in the pathogenesis of various diseases, including cardiovascular disease, Alzheimer's disease and intestine‐associated disease. This review discusses the current findings on the role of sEH in the development of intestine‐ and intestine‐associated diseases, including colitis, colorectal cancer, and other intestinal diseases, as well as the potential underlying mechanisms involved.