Affiliation:
1. Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College Hubei University of Science and Technology Xianning China
2. School of Basic Medical Sciences, Xianning Medical College Hubei University of Science and Technology Xianning China
3. School of Public Health and Nursing, Xianning Medical College Hubei University of Science and Technology Xianning China
4. School of Nuclear Technology and Chemistry & Biology Hubei University of Science and Technology Xianning China
Abstract
AbstractDiabetic nephropathy (DN) is the predominant secondary nephropathy resulting in global end‐stage renal disease. It is attracting significant attention in both domestic and international research due to its widespread occurrence, fast advancement, and limited choices for prevention and treatment. The pathophysiology of this condition is intricate and involves multiple molecular and cellular pathways at various levels. This article provides a concise overview of the molecular processes involved in the development of DN. It discusses various factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, cellular damage, autophagy, and epigenetics. The aim is to offer clinicians a valuable reference for DN's diagnosis, treatment, and intervention.
Funder
Natural Science Foundation of Hubei Province