Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis

Author:

Al‐Hawary Sulieman I. Shelash1,Altalbawy Farag M. A.2,Jasim Saade Abdalkareem3ORCID,Jyothi S Renuka4,Jamal Azfar56ORCID,Naiyer Mohammed M.7ORCID,Mahajan Shriya8,Kalra Hitesh9,Jawad Mohammed Abed10,Zwamel Ahmed Hussein111213

Affiliation:

1. Al Al‐Bayt University Mafraq Jordan

2. Department of Chemistry University College of Duba, University of Tabuk Tabuk Saudi Arabia

3. Medical Laboratory Techniques Department, College of Health and Medical Technology University of Al‐Maarif Anbar Iraq

4. Department of Biotechnology and Genetics School of Sciences, JAIN (Deemed to be University) Bangalore Karnataka India

5. Health and Basic Science Research Centre Majmaah University Al‐Majmaah Saudi Arabia

6. Department of Biology College of Science Al‐Zulfi, Majmaah University Al‐Majmaah Saudi Arabia

7. Department of Pharmaceutics UCL School of Pharmacy, University College London London UK

8. Department of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan India

9. Chandigarh Pharmacy College Chandigarh Group of Colleges, Jhanjheri Mohali Punjab India

10. Department of Pharmaceutics Al‐Nisour University College Baghdad Iraq

11. Medical Laboratory Technique College The Islamic University Najaf Iraq

12. Medical Laboratory Technique College The Islamic University of Al Diwaniyah Al Diwaniyah Iraq

13. Medical Laboratory Technique College The Islamic University of Babylon Babylon Iraq

Abstract

AbstractThis study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified as a crucial factor in the development and progression of breast cancer. The essay explains the complex molecular mechanisms through which mTOR inhibitors, such as rapamycin and its analogs, exert their anticancer effects. These inhibitors can stop cell growth, proliferation, and survival in breast cancer cells by blocking critical signaling pathways within the mTOR pathway. Furthermore, the essay discusses the implications of using mTOR inhibitors as a comprehensive therapeutic strategy. It emphasizes the potential benefits of combining mTOR inhibitors with other treatment approaches to enhance the effectiveness of breast cancer treatment. The evolving landscape of breast cancer research underscores the significance of mTOR as a therapeutic target and highlights ongoing efforts to improve and optimize mTOR inhibitors for clinical use. In conclusion, the essay asserts that inhibitors of the mTOR signaling pathway offer a promising approach in the fight against breast cancer. These inhibitors provide a focused and effective intervention targeting specific dysregulations within the mTOR pathway. As research advances, the integration of mTOR inhibitors into customized combination therapies holds excellent potential for shaping a more effective and personalized approach to breast cancer treatment, ultimately leading to improved outcomes for individuals affected by this complex and diverse disease.

Funder

Majmaah University

Publisher

Wiley

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