Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2

Author:

Kuscuoglu Deniz1,Bewersdorf Lisa1,Wenzel Kathrin1,Gross Annika1,Kobazi Ensari Gökce1,Luo Yizhao1,Kilic Konrad1,Hittatiya Kanishka2,Golob‐Schwarzl Nicole3,Leube Rudolf E4,Preisinger Christian5,George Jacob6,Metwally Mayada6,Eslam Mohammed6,Lampertico Pietro7,Petta Salvatore8,Mangia Alessandra9,Berg Thomas10,Boonstra Andre11,Brouwer Willem P11,Abate Maria Lorena12,Loglio Alessandro7,Sutton Angela131415,Nahon Pierre161718,Schaefer Benedikt19,Zoller Heinz19,Aigner Elmar20,Trautwein Christian1,Haybaeck Johannes2122,Strnad Pavel1ORCID

Affiliation:

1. Department of Medicine III University Hospital Aachen Aachen Germany

2. Institute of Pathology University Hospital Bonn Bonn Germany

3. Institute of Dermatology University Hospital Graz Graz Austria

4. Institute of Molecular and Cellular Anatomy RWTH Aachen University Aachen Germany

5. Proteomics Facility, Interdisciplinary Centre for Clinical Research (IZKF), Medical School RWTH Aachen University Aachen Germany

6. Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney Sydney Australia

7. CRC ‘A. M. e A. Migliavacca’ Center for Liver Disease Division of Gastroenterology and Hepatology Fondazione IRCCS Ca' Granda – Ospedale Maggiore Policlinico Università di Milano Milan Italy

8. Sezione di Gastroenterologia e Epatologia, DiBiMIS University of Palermo Palermo Italy

9. Division of Hepatology Ospedale Casa Sollievo della Sofferenza, IRCCS San Giovanni Rotondo Italy

10. Section of Hepatology, Clinic for Gastroenterology and Rheumatology University Clinic Leipzig Leipzig Germany

11. Department of Gastroenterology and Hepatology Erasmus MC ‐ University Medical Center Rotterdam Rotterdam The Netherlands

12. Division of Gastroenterology and Hepatology, Department of Medical Science University of Turin Turin Italy

13. Centre de Ressources Biologiques (Liver Disease Biobank) Groupe Hospitalier Paris Seine‐Saint‐Denis France

14. AP‐HP Hôpital Jean Verdier, Service de Biochimie Bondy France

15. Inserm U1148, Université Paris 13 Bobigny France

16. AP‐HP, Hôpital Jean Verdier, Service d'Hépatologie Bondy France

17. Université Paris 13, Sorbonne Paris Cité, ‘Equipe Labellisée Ligue Contre le Cancer’ Saint‐Denis France

18. Inserm, UMR‐1162, ‘Génomique Fonctionnelle des Tumeur Solides’ Paris France

19. Department of Internal Medicine I Medical University of Innsbruck Innsbruck Austria

20. First Department of Medicine Paracelsus Medical University Salzburg Austria

21. Department of Pathology, Medical Faculty Otto‐von‐Guericke University Magdeburg Magdeburg Germany

22. Department of Pathology, Neuropathology and Molecular Pathology Medical University of Innsbruck Innsbruck Austria

Funder

Deutsche Forschungsgemeinschaft

National Health and Medical Research Council

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference58 articles.

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