Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells-Reference-Cited by-同舟云学术

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Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells

Published:2022-04-05 Issue:7 Volume:119 Page:1712-1727
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Sacco Sarah A.¹,Tuckowski Angela M.²,Trenary Irina¹,Kraft Lauren²,Betenbaugh Michael J.³^ORCID,Young Jamey D.¹⁴^ORCID,Smith Kevin D.²

Affiliation:

1. Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville Tennessee USA

2. Biotherapeutics Development Janssen Research and Development Spring House Pennsylvania USA

3. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland USA

4. Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA

Funder

National Science Foundation

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28084

Reference53 articles.

1. What's fueling the biotech engine—2012 to 2013

2. Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

3. Measuring Deuterium Enrichment of Glucose Hydrogen Atoms by Gas Chromatography/Mass Spectrometry

4. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing

5. Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

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1. Understanding resource competition to achieve predictable synthetic gene expression in eukaryotes;Nature Reviews Bioengineering;2024-07-04

2. Metabolomic characterization of monoclonal antibody‐producing Chinese hamster lung (CHL)‐YN cells in glucose‐controlled serum‐free fed‐batch operation;Biotechnology and Bioengineering;2024-06-22

3. Overexpression of peroxisome proliferator-activated receptor co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity;Metabolic Engineering;2023-09

4. Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer;Expert Opinion on Therapeutic Targets;2023-08-03

5. Weak promoters to drive selection marker expression: Improvement of cell line development process for therapeutic protein production in CHO-K1 cells;Journal of Biotechnology;2023-06

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