Gastrointestinal amyloidosis in a 50‐year‐old patient with miliary tuberculosis: A case report

Author:

Rauf Sameer Abdul1ORCID,Shah Hussain Haider2ORCID,Khatri Rahul1,Ul Haq Mansoor3,Dave Tirth4ORCID,Ali Javaria Parwez5,Ali Syed Khizar1

Affiliation:

1. Department of Internal Medicine Liaquat National Hospital and Medical College Karachi Pakistan

2. Department of Internal Medicine Dow University of Health Sciences Karachi Pakistan

3. Department of Gastroenterology Liaquat National Hospital and Medical College Karachi Pakistan

4. Bukovinian State Medical University Chernivtsi Ukraine

5. Department of Histopathology Liaquat National Hospital and Medical College Karachi Pakistan

Abstract

Key Clinical MessageThis case highlights the importance of considering tuberculosis as an underlying cause of gastrointestinal amyloidosis, even in patients previously treated for the infection. Clinicians should maintain a high index of suspicion for atypical presentations of amyloidosis, especially in individuals with chronic inflammation, enabling early diagnosis and tailored management for improved patient outcomes.AbstractGastrointestinal amyloidosis is a rare condition often associated with chronic inflammation. We present a unique case of a 50‐year‐old female with a history of miliary tuberculosis who developed gastrointestinal amyloidosis. The patient exhibited chronic loose stools, weight loss, abdominal pain, and urinary incontinence symptoms. Diagnostic workup revealed characteristic findings of amyloidosis on biopsy. Despite treatment for tuberculosis, her symptoms persisted, highlighting the challenging nature of managing this condition. This case underscores the importance of considering tuberculosis as a potential cause of secondary amyloidosis in patients with ongoing symptoms of inflammation and infection. Early recognition and tailored management are crucial in optimizing patient outcomes.

Publisher

Wiley

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