In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

Author:

Bhatia Hemlata1,Mehdizadeh Hamidreza2,Drapeau Denis3,Yoon Seongkyu4

Affiliation:

1. Department of Biomedical Engineering and Biotechnology; University of Massachusetts Lowell; Lowell MA, USA

2. Advanced Manufacturing Technology; Global Technology Services; Pfizer Global Supplies; Pfizer-Inc.; Peapack NJ, USA

3. Bioprocess R&D; Pfizer-Inc.; Andover MA, USA

4. Department of Chemical Engineering; University of Massachusetts Lowell; Lowell MA, USA

Publisher

Wiley

Subject

Bioengineering,Environmental Engineering,Biotechnology

Reference36 articles.

1. US-FDA Guidance for Industry PAT - A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance U.S.D.o.H.a.H. Services, Editor. 2004, Pharmaceutical CGMPs. 2004

2. Optical sensor systems for bioprocess monitoring;Ulber;Anal. Bioanal. Chem.,2003

3. Near Infrared spectroscopy for rapid, simultaneous monitoring of multiple components in mammalian cell culture;Card;BioProcess. Int.,2008

4. Rogge , P. Laukel , M. Dudziak , G. Disposable Downstream Processing for Clinical Manufacturing, in Bioprocess International 2011

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