A lipase-catalyzed process for green synthesis of temsirolimus

Author:

Ju Xin12,Li Jianyong3,Hou Maoqi1,Tao Junhua1

Affiliation:

1. EnzymeWorks Inc; Suzhou China

2. School of Chemistry; Biology and Material Engineering; University of Science and Technology of Suzhou; Suzhou China

3. Hangzhou Huadong Medicine Group Pharmaceutical Research Institute Co., Ltd; Hangzhou China

Funder

Suzhou Technology Division

Publisher

Wiley

Subject

Bioengineering,Environmental Engineering,Biotechnology

Reference24 articles.

1. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR;Neshat;Proc. Natl. Acad. Sci. USA,2001

2. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy;Geoerger;Cancer Res.,2001

3. Rapamune (RAPA, rapamycin, sirolimus): Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression;Sehgal;Clin. Biochem.,1998

4. Shaw , C. Sellstedt , J. Noureldin , R. Cheal , G. K. Regioselective synthesis of rapamycin derivatives 2001

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