<scp>HPV</scp>‐negative head and neck cancers with adverse pathological features carry specific molecular changes that are associated with survival-Reference-Cited by-同舟云学术

HPV‐negative head and neck cancers with adverse pathological features carry specific molecular changes that are associated with survival

Published:2023-12-07 Issue:2 Volume:46 Page:353-366
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Kim Hugh Andrew Jinwook¹^ORCID,Zeng Peter Y. F.²,Cecchini Matthew³,Shaikh Mushfiq Hassan²,Laxague Francisco²,Deng Xiaoxiao²,Jarycki Laura²,Ryan Sarah Elizabeth Belle²³,Dawson Alice²³,Liu Mu Han²,Palma David A.²⁴^ORCID,Patel Krupal⁵^ORCID,Mundi Neil⁶,Barrett John W.²⁴^ORCID,Mymryk Joe S.²⁴⁷^ORCID,Boutros Paul C.⁸⁹¹⁰¹¹¹²,Nichols Anthony C.²⁴^ORCID

Affiliation:

1. Department of Otolaryngology—Head and Neck Surgery University of Toronto Toronto Ontario Canada

2. Department of Otolaryngology—Head and Neck Surgery University of Western Ontario London Ontario Canada

3. Department of Pathology and Laboratory Medicine University of Western Ontario London Ontario Canada

4. Department of Oncology University of Western Ontario London Ontario Canada

5. Department of Otolaryngology—Head & Neck Surgery Moffitt Cancer Center Tampa Florida USA

6. Department of Otolaryngology—Head & Neck Surgery Southern Illinois University School of Medicine Springfield Illinois USA

7. Department of Microbiology & Immunology University of Western Ontario London Ontario Canada

8. Department of Human Genetics University of California Los Angeles California USA

9. Department of Urology University of California Los Angeles California USA

10. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California Los Angeles California USA

11. Institute for Precision Health University of California Los Angeles California USA

12. Jonsson Comprehensive Cancer Centre University of California Los Angeles California USA

Abstract

AbstractBackgroundAdverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features.MethodsWe downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis.ResultsAll pathological features were associated with poor survival, as were the following molecular changes: low cyclin E1 (HR = 1.7) and high PKC‐alpha (HR = 1.8) in tumors with PNI; six of 13 protein abundance changes with LVI; greater tumor hypoxia and high Raptor (HR = 2.0) and Rictor (HR = 1.6) with ECS; and low p38 (HR = 2.3), high fibronectin (HR = 1.6), low annexin A1 (HR = 3.1), and high caspase‐9 (HR = 1.6) abundances with PSM.ConclusionsPathological features in HNSCC carry specific molecular changes that may explain their poor prognostic associations.

Funder

Canadian Institutes of Health Research

National Institutes of Health

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27591

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