Periplocin inhibits the growth of pancreatic cancer by inducing apoptosis via AMPK‐mTOR signaling

Author:

Xie Gangyin1,Sun Linxiao1,Li Yonglin1,Chen Bicheng1,Wang Cheng1ORCID

Affiliation:

1. Key Laboratory of Diagnosis and Treatment of Severe Hepato‐Pancreatic Diseases of Zhejiang Province Zhejiang Provincial Top Key Discipline in Surgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China

Funder

Natural Science Foundation of Zhejiang Province

Wenzhou Municipal Science and Technology Bureau

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference37 articles.

1. Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations

2. Periplocin from Cortex periplocae inhibits cell growth and down‐regulates survivin and c‐myc expression in colon cancer in vitro and in vivo via beta‐catenin/TCF signaling;Zhao L;Oncol Rep,2010

3. Periplocin inhibits growth of lung cancer in vitro and in vivo by blocking AKT/ERK signaling pathways;Lu ZJ;Cell Physiol Biochem,2010

4. Periplocin Extracted from Cortex Periplocae Induced Apoptosis of Gastric Cancer Cells via the ERK1/2-EGR1 Pathway

5. Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis

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