Preclinical evaluation of [ 11 C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone-Reference-Cited by-同舟云学术

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Preclinical evaluation of [ 11 C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone

Published:2020-12-02 Issue:4 Volume:64 Page:159-167
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J Label Compd Radiopharm

Author:

Bennacef Idriss¹^ORCID,Rubins Daniel¹,Riffel Kerry¹,Williams Mangay¹,Posavec Diane J.¹,Holahan Marie A.¹,Purcell Mona L.¹,Haley Hyking D.¹,Wolf Mary¹,Stachel Shawn J.²,Lubbers Laura S.³,Wesolowski Gregg A.⁴,Duong Le T.⁴,Hamill Terence G.¹,Evelhoch Jeffrey L.¹,Hostetler Eric D.¹

Affiliation:

1. Translational Biomarkers—Imaging Merck & Co., Inc. Kenilworth NJ USA

2. Discovery Chemistry Merck & Co., Inc. Kenilworth NJ USA

3. In Vitro Pharmacology Merck & Co., Inc. Kenilworth NJ USA

4. Bone Biology Merck & Co., Inc. Kenilworth NJ USA

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jlcr.3896

Reference12 articles.

1. Advanced CT bone imaging in osteoporosis

2. Breaking new ground to build bone

3. Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

4. Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities

5. Bone Density, Turnover, and Estimated Strength in Postmenopausal Women Treated With Odanacatib: A Randomized Trial

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