Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti‐Infective Agents: A Systematic Literature Review From the ARITMO Project

Author:

Hazell Lorna1,Raschi Emanuel2,Ponti Fabrizio2,Thomas Simon H. L.3,Salvo Francesco4,Ahlberg Helgee Ernst5,Boyer Scott6,Sturkenboom Miriam7,Shakir Saad1

Affiliation:

1. Drug Safety Research Unit Southampton United Kingdom

2. Department of Medical and Surgical SciencesUniversity of Bologna Bologna Italy

3. Institute of Cellular MedicineFaculty of MedicineNewcastle University Newcastle United Kingdom

4. University of Bordeaux U657CHU de Bordeaux Bordeaux France

5. Drug Safety and MetabolismAstraZeneca Innovative Medicines and Early Development Mölndal Sweden

6. Computational Toxicology, Swedish Toxicology Sciences Research Center Södertälje Sweden

7. Medical InformaticsErasmus University Rotterdam The Netherlands

Funder

Seventh Framework Programme

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference129 articles.

1. Torsades de pointes: A review

2. International Conference on Harmonisation; guidance on E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non‐antiarrhythmic drugs; availability notice;ICH;Fed Regist,2005

3. Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice

4. Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative

5. A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays

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