1. Department of Earth and Environmental Sciences; University of Milan Bicocca; Piazza della Scienza, 1 20126 Milan Italy
2. European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Chemical Safety and Alternative Methods Unit; Directorate F, European Commission Joint Research Centre; TP 126, Via E. Fermi 2749, I-21027 Ispra (VA) Italy
3. Department of Statistics, Computer Science; Applications, University of Florence; Viale Morgagni 59 I-50100 Florence Italy