Bioactivation of lumiracoxib in human liver microsomes: Formation of GSH‐ and amino adducts through acyl glucuronide-Reference-Cited by-同舟云学术

Bioactivation of lumiracoxib in human liver microsomes: Formation of GSH‐ and amino adducts through acyl glucuronide

Published:2020-02-19 Issue:6 Volume:12 Page:827-835
ISSN:1942-7603
Container-title:Drug Testing and Analysis
language:en
Short-container-title:Drug Test Anal

Author:

Jiao Weijie¹,Zhao Xu¹,Wu Guiyue¹,Zhang Xiangyun¹,Wu Hong²,Cui Yinglin³^ORCID

Affiliation:

1. Department of PharmacyHenan Province Hospital of Traditional Chinese Medicine Zhengzhou Henan Province China

2. Laboratory of Cell ImagingHenan University of Chinese Medicine Zhengzhou Henan Province China

3. Henan Province Hospital of Traditional Chinese MedicineThe Second Clinical Medical College of Henan University of Chinese Medicine Zhengzhou Henan Province China

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dta.2777

Reference17 articles.

1. Lumiracoxib in the management of osteoarthritis and acute pain

2. Hepatotoxicity induced by coxibs: how concerned should we be?

3. Safety data and withdrawal of hepatotoxic drugs

4. Nonsteroidal Anti-Inflammatory Drug–Induced Hepatoxicity

5. In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry and Compound Discoverer software;Biomedical Chromatography;2023-07-16

2. Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery;Drug Discovery Today;2023-07

3. Identification and characterization of the metabolites of moscatilin in mouse, rat, dog, monkey and human hepatocytes by LC–Orbitrap–MS/MS combined with diagnostic fragment ions and accurate mass measurements;Biomedical Chromatography;2022-12-26

4. Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats;Xenobiotica;2022-07-03

5. A validated UHPLC–MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: Application to a pharmacokinetic study;Journal of Pharmaceutical and Biomedical Analysis;2021-07