Locked nucleic acid (LNA)-based single-stranded oligonucleotides are not genotoxic-Reference-Cited by-同舟云学术

Locked nucleic acid (LNA)-based single-stranded oligonucleotides are not genotoxic

Published:2017-03-10 Issue:3 Volume:58 Page:112-121
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ. Mol. Mutagen.

Author:

Guérard Melanie¹,Andreas Zeller¹,Erich Koller¹,Christine Marchand¹,Martina Müller B.¹,Christian Weile²,Franz Schuler¹,Thomas Singer¹,Yann Tessier²

Affiliation:

1. Pharmaceutical Sciences, Roche Innovation Center Basel, Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Ltd; Basel 4070 Switzerland

2. Roche Innovation Center Copenhagen A/S, Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Ltd; Hørsholm 2970 Denmark

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/em.22076/fullpdf

Reference40 articles.

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2. Sequence motifs associated with hepatotoxicity of locked nucleic acid-modified antisense oligonucleotides;AD;Nucleic Acids Res.,2014

3. EMEA/CHMP/SWP/199726/2004 2005 CHMP SWP reflection paper on the assessment of the genotoxic potential of antisense oligonucleotides

4. The ability of the mouse lymphoma TK assay to detect aneugens;Fellows;Mutagenesis,2011

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