Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

Author:

Ramakrishnan Vidya1ORCID,Friedrich Christina2,Witt Colleen2,Sheehan Robert2,Pryor Meghan2,Atwal Jasvinder K.1,Wildsmith Kristin1,Kudrycki Katherine2,Lee Seung‐Hye1,Mazer Norman3,Hofmann Carsten3,Fuji Reina N.1,Jin Jin Y.1ORCID,Ramanujan Saroja1,Dolton Michael4,Quartino Angelica1

Affiliation:

1. Genentech, Inc. South San Francisco California USA

2. Rosa & Co., LLC. San Carlos California USA

3. F. Hoffmann‐La Roche Ltd Basel Switzerland

4. Roche Products Australia Pty Ltd New South Wales Sydney Australia

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference50 articles.

1. 2021 Alzheimer's disease facts and figures

2. Mild Cognitive Impairment;Petersen RC;Continuum (Minneap Minn),2016

3. Clinical trials of new drugs for Alzheimer disease

4. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

5. FDA.FDA Grants Accelerated Approval for Alzheimer's Drug.https://www.fda.gov/news‐events/press‐announcements/fda‐grants‐accelerated‐approval‐alzheimers‐drug. Accessed January 18 2022.

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