Application of physiologically‐based pharmacokinetic model approach to predict pharmacokinetics and drug–drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine

Author:

Ngo Lien Thi1ORCID,Yang Sung‐yoon1,Shin Sooyoung2ORCID,Cao Duc Tuan3ORCID,Van Nguyen Hung4ORCID,Jung Sangkeun5,Lee Jae‐Young5,Lee Jong‐Hwa67,Yun Hwi‐yeol1ORCID,Chae Jung‐woo1ORCID

Affiliation:

1. College of Pharmacy Chungnam National University Daejeon Korea

2. College of Pharmacy Ajou University Suwon Korea

3. Department of Pharmaceutical Chemistry and Quality Control Faculty of Pharmacy, Haiphong University Medicine and Pharmacy Haiphong Vietnam

4. Department of Pharmacology, Faculty of Pharmacy Haiphong University Medicine and Pharmacy Haiphong Vietnam

5. Department of Computer Science and Engineering Chungnam National University Daejeon Korea

6. Korea Institute of Toxicology Daejeon Korea

7. Department of Human and Environment Toxicology University of Science and Technology Daejeon Korea

Funder

Korea Environmental Industry and Technology Institute

National Research Foundation of Korea

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference42 articles.

1. Bayer Pharma AGXarelto (rivaroxaban) Summary of Product Characteristics;2013.https://www.ema.europa.eu/en/documents/product‐information/xarelto‐epar‐product‐information_en.pdf

2. European Medicines Agency.CHMP assessment report for Xarelto;2008.https://www.ema.europa.eu/en/documents/assessment‐report/xarelto‐epar‐public‐assessment‐report_en.pdf

3. Clinical Pharmacokinetic and Pharmacodynamic Profile of Rivaroxaban

4. Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects

5. In Vitro and In Vivo P-Glycoprotein Transport Characteristics of Rivaroxaban

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