Affiliation:
1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center Fudan University Shanghai China
2. Department of Oncology Shanghai Medical College Fudan University Shanghai China
3. Shanghai Clinical Research Center for Radiotherapy Oncology Shanghai Key Laboratory of Radiation Oncology Shanghai China
Abstract
AbstractBackgroundThere is considerable heterogeneity in clinical behavior and survival outcomes in patients with cholangiocarcinoma (CCA), and the prognosis of CCA patients is poor. We proposed lymphocyte to monocyte ratio (LMR) as a novel prognostic element for CCA patients with hepatic resection in present study.MethodsBy retrospectively analyzing the clinical data of 145 CCA patients with hepatic resection, we determined the optimal LMR cutoff value according to the receiver operating characteristic (ROC). We comparatively analyzed the clinical features of CAA patients between low LMR group and high LMR group, mainly including overall survival (OS) analysis by using the Kaplan‐Meier method, univariate and multivariate Cox regression.ResultsWe found there was a longer OS in CCA patients of the high LMR group than the low LMR group. The total median OS of cholangiocarcinoma patients were 13.6 months, and the OS of low LMR group was markedly lower than the high LMR group. The 1‐year, 3‐year, and 5‐year OS of high LMR group were respectively 62.9%, 32.4%, and 16.4%, and were significantly higher the cholangiocarcinoma patients of low LMR group (40.2%, 16.4%, and 0%). Multivariate regression analyses showed that preoperative cholangitis, elevated CEA level and nerve invasion were risk factors for the OS of cholangiocarcinoma patients, while the high LMR level and postoperative treatment were protective factors for the OS of cholangiocarcinoma patients.ConclusionsPreoperative LMR was a vital prognostic factor to predict the prognosis of CCA patients with hepatic resection and provided additional prognostic value beyond standard clinicopathological parameters.
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology
Cited by
5 articles.
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