TheAPCVariant p.Glu1317Gln predisposes to colorectal adenomas by a novel mechanism of relaxing the target for tumorigenic somaticAPCmutations

Author:

Dallosso Anthony R.,Jones Siân,Azzopardi Duncan,Moskvina Valentina,Al-Tassan Nada,Williams Geraint T.,Idziaszczyk Shelley,Davies D. Rhodri,Milewski Peter,Williams Sally,Beynon John,Sampson Julian R.,Cheadle Jeremy P.

Publisher

Wiley

Subject

Genetics(clinical),Genetics

Reference21 articles.

1. The “just-right” signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade;Albuquerque;Hum Mol Genet,2002

2. Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors;Al-Tassan;Nat Genet,2002

3. Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas;Azzopardi;Cancer Res,2008

4. Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours;Cheadle;Cancer Res,2002

5. The ABC of APC;Fearnhead;Hum Mol Genet,2001

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