<scp>DNA</scp> Methylation Age Acceleration as a Potential Biomarker for Early Onset of <scp>Rapid Eye Movement</scp> Sleep Behavior Disorder-Reference-Cited by-同舟云学术

DNA Methylation Age Acceleration as a Potential Biomarker for Early Onset of Rapid Eye Movement Sleep Behavior Disorder

Published:2023-10-19 Issue:1 Volume:95 Page:190-194
ISSN:0364-5134
Container-title:Annals of Neurology
language:en
Short-container-title:Annals of Neurology

Author:

Senkevich Konstantin¹²³^ORCID,Pelletier Amélie⁴,Sato Christine³,Liu Lang¹²,Keil Allison²,Gan‐Or Ziv¹²⁵^ORCID,Lang Anthony E.³⁶⁷⁸,Postuma Ronald B.²⁴⁹,Rogaeva Ekaterina³⁸^ORCID

Affiliation:

1. The Neuro (Montreal Neurological Institute–Hospital), McGill University Montreal QC Canada

2. Department of Neurology and Neurosurgery McGill University Montreal QC Canada

3. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto ON Canada

4. Center for Advanced Studies in Sleep Medicine Montreal Sacre Coeur Hospital Montreal QC Canada

5. Department of Human Genetics McGill University Montreal QC Canada

6. Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital Toronto ON Canada

7. Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital Toronto ON Canada

8. Division of Neurology, Department of Medicine University of Toronto Toronto ON Canada

9. Research Institute of McGill University Health Centre Montreal QC Canada

Abstract

Rapid eye movement sleep behavior disorder (RBD) is the strongest prodromal marker for α‐synucleinopathies. The Horvath DNA methylation age (DNAm‐age) is an epigenetic clock reflecting biological aging. We found an association of DNAm‐age acceleration with RBD age at onset at baseline (N = 162, B = −0.68, standard error [SE] = 0.12, p = 2.59e‐08) and follow‐up (n = 45, B = −1.07, SE = 0.21, p = 9.73e‐06). The result remained similar after accounting for genetic risk factors (eg, RBD polygenic risk score). On average, RBD patients with faster versus slow/normal epigenetic aging had a 5.2‐year earlier phenoconversion, and the Cox regression analysis revealed a trend toward significance (n = 53, hazard ratio = 1.05, 95% confidence interval = 0.99–1.11, p = 0.06). Our findings suggest that DNAm‐age acceleration is a potential biomarker for earlier RBD onset. ANN NEUROL 2024;95:190–194

Funder

Consortium canadien en neurodégénérescence associée au vieillissement

FRQS

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.26811

Reference24 articles.

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