Synthesis, Characterization andin vitroStudies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib

Author:

Karnthaler-Benbakka Claudia1,Koblmüller Bettina2,Mathuber Marlene1,Holste Katharina2,Berger Walter23,Heffeter Petra23,Kowol Christian R.13ORCID,Keppler Bernhard K.13

Affiliation:

1. Institute of Inorganic Chemistry, Faculty of Chemistry; University of Vienna; Waehringer Straße 42 AT-1090 Wien

2. Institute of Cancer Research and Comprehensive Cancer Center; Medical University of Vienna; Borschkegasse 8 A AT-1090 Wien

3. Research Cluster ‘Translational Cancer Therapy Research'; University of Vienna and Medical University of Vienna; AT-1090 Wien

Funder

Initiative Krebsforschung of the Medical University Vienna

Austrian Science Fund

P28853

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Reference33 articles.

1. J. Med. Pharm. Chem 1959 1

2. Curr. Med. Chem 2008 15

3. ChemMedChem 2008 3

4. Nat. Rev. Cancer 2011 11

5. Adv. Drug Delivery Rev 2016 97

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