Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA-4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3-Dioxygenase Pathway
Author:
Affiliation:
1. Kennedy Institute and University of Oxford; Oxford UK
2. Northwick Park Hospital; Harrow UK
Funder
The Kennedy Trust for Rheumatology Research
Publisher
Wiley
Subject
Immunology,Rheumatology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/art.38715/fullpdf
Reference44 articles.
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3. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis;Flores-Borja;Proc Natl Acad Sci U S A,2008
4. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis;Viglietta;J Exp Med,2004
5. Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes;Lindley;Diabetes,2005
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