Affiliation:
1. National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology Jiangnan University Wuxi China
2. Binzhou Zhongyu Food Company Limited, Key Laboratory of Wheat Processing, Ministry of 12 Agriculture and Rural Affairs, National Industry Technical Innovation Center for Wheat 13 Processing, Bohai Advanced Technology Institute Binzhou China
Abstract
AbstractBACKGROUNDRecently, peptides have been studied in Caenorhabditis elegans for anti‐aging research. Due to the lack of sufficient evidence, we conducted this meta‐analysis focusing on the anti‐aging effect of peptides in C. elegans to provide more convincing evidence.RESULTSA literature search in PubMed, SCOUPUS, and Web of Science databases yielded 2879 articles. After removing duplicates and based on inclusion criteria and STAIR checklist quality assessment, nine articles were selected. Data extraction and analysis showed that, compared to the control group without peptide intervention, peptide supplementation significantly reduced nematode mortality risk [hazard ratio = 0.54, 95% confidence interval (CI) = 0.47, 0.62; P < 0.05], significantly increased the pharyngeal pumping rate [standardized mean difference (SMD) = 1.64, 95% CI = 0.87, 2.41; P < 0.05], bending frequency (SMD = 1.67, 95% CI = 1.16, 2.18; P < 0.05), and significantly decreased the accumulation of lipofuscin levels within nematodes (SMD = −4.48, 95% CI = −6.85, −2.12; P < 0.05). Additionally, subgroup analysis showed that doses ranging from 0.1 to 1 mg/mL (HR = 0.50, 95% CI = 0.38, 0.65; P < 0.05) displayed better anti‐aging effects compared to other dose ranges.CONCLUSIONThe findings suggest that peptides can significantly extend the lifespan of C. elegans under normal circumstances and improve three indicators of healthy life. More importantly, subgroup analysis revealed that a dosage of 0.1–1 mg/mL demonstrated superior anti‐aging effects. This meta‐analysis provides more convincing evidence that peptides can play an anti‐aging role in C. elegans. © 2024 Society of Chemical Industry.