The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors

Author:

Bergare Jonas1,Kingston Lee1ORCID,Guly Dominic J.2,Dolan James2,Lewis Richard J.3ORCID,Elmore Charles S.1ORCID

Affiliation:

1. Isotope Chemistry, Pharmaceutical Science, R&D; AstraZeneca; Gothenberg Sweden

2. Key Organics Ltd; Highfield Road Industrial Estate; Camelford PL32 9RA UK

3. Medicinal Chemistry, Research and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D; AstraZeneca; Gothenberg Sweden

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Asthma;Fanta;N Engl J Med,2009

2. New therapies and management strategies in the treatment of asthma: patient-focused developments;Agbetile;J Asthma Allergy,2011

3. Drugs that target Lipoxygenases and Leukotrienes as emerging therapies for asthma and cancer;Candace;Current Drug Targets - Inflammation & Allergy,2004

4. Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D4 receptor antagonist;Jones;Can J Physiol Pharmacol,1995

5. Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles;Matassa;J Med Chem,1990

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