A controversial question: Can morphometry and clinical history be enough to diagnose hippocampal dysplasia?-Reference-Cited by-同舟云学术

A controversial question: Can morphometry and clinical history be enough to diagnose hippocampal dysplasia?

Published:2024-04-08 Issue:3 Volume:26 Page:382-391
ISSN:1294-9361
Container-title:Epileptic Disorders
language:en
Short-container-title:Epileptic Disorders

Author:

Arruda Ianne Lucena¹²,Arruda Rivus Ferreira¹²,da Silveira Rayanne Maria Brandão¹,Duarte Jeana Torres Corso¹,Guaranha Mirian Salvadori Bittar¹^ORCID,Guilhoto Laura Maria¹^ORCID,Carrete Júnior Henrique³^ORCID,Stavale Joao Norberto⁴,Centeno Ricardo Silva⁵^ORCID,Yacubian Elza Marcia Targas¹^ORCID,Peixoto‐Santos Jose Eduardo²^ORCID

Affiliation:

1. Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery Federal University of São Paulo (Unifesp) São Paulo Brazil

2. Neuroscience Sector, Department of Neurology and Neurosurgery Federal University of São Paulo (UNIFESP) São Paulo Brazil

3. Diagnostic Imaging Sector, Department of Diagnostic Imaging Federal University of São Paulo (Unifesp) São Paulo Brazil

4. Department of Pathology Federal University of São Paulo (Unifesp) São Paulo Brazil

5. Neurosurgery Sector, Department of Neurology and Neurosurgery Federal University of São Paulo (Unifesp) São Paulo Brazil

Abstract

AbstractThe presence of dysmorphic neurons with strong cytoplasmatic accumulation of heavy non‐phosphorylated neurofilament is crucial for the diagnostics of focal cortical dysplasia type II (FCDII). While ILAE's classification describes neocortical dysplasias, some groups have reported patients with mesial t abnormal neurons in the hippocampus of mesial temporal lobe epilepsy. Here we report a patient with such abnormal neurons in the hippocampus and compared it with previous reports of hippocampal dysplasia. Finally, we discuss the need for diagnostic criteria of hippocampal dysplasia.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/epd2.20222

Reference19 articles.

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3. Pathophysiological implications of focal cortical dysplasia of end folium for hippocampal sclerosis

4. Balloon cells and dysmorphic neurons in the hippocampus associated with epileptic amnesic syndrome: A case report

5. Hippocampal dysplasia with balloon cells: case report and discussion on classification