Iron-chelating effect of silymarin in patients with β-thalassemia major: A crossover randomised control trial

Author:

Darvishi-Khezri Hadi1,Salehifar Ebrahim2ORCID,Kosaryan Mehrnoush3,Karami Hossein3,Mahdavi Mohammadreza4,Alipour Abbas5,Aliasgharian Aily6

Affiliation:

1. Department of Nursing, Sari Branch; Islamic Azad University; Sari Iran

2. Department of Clinical Pharmacology, Thalassemia Research Center, Hemoglobinopathy Institute; Mazandaran University of Medical Sciences; Mazandaran Sari Iran

3. Department of Pediatrics, Thalassemia Research Center, Hemoglobinopathy Institute; Mazandaran University of Medical Sciences; Mazandaran Sari Iran

4. PhD in Medical Genetics, Thalassemia Research Center, Hemoglobinopathy Institute; Mazandaran University of Medical Sciences; Mazandaran Sari Iran

5. Department of Community Medicine, Thalassemia Research Center, Hemoglobinopathy Institute; Mazandaran University of Medical Sciences; Mazandaran Sari Iran

6. Student Research Committee, MSc in Medical Microbiology, Thalassemia Research Center, Hemoglobinopathy Institute; Mazandaran University of Medical Sciences; Mazandaran Sari Iran

Funder

Mazandaran University of Medical Sciences

Publisher

Wiley

Subject

Pharmacology

Reference38 articles.

1. Milk thistle in liver diseases: Past, present, future;Abenavoli;Phytotherapy Research,2010

2. Therapeutic effects of deferoxamine and silymarin versus deferoxamine alone in β-thalassemia major based on findings of liver MRI;Adibi;Journal of Research in Medical Sciences,2012

3. Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants;Amer;British Journal of Haematology,2006

4. Serum levels of TGFβ, IL-10, IL-17, and IL-23 cytokines in β-thalassemia major patients: The impact of silymarin therapy;Balouchi;Immunopharmacology and Immunotoxicology,2014

5. Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C;Bares;Journal of Clinical Gastroenterology,2008

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