Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein-Reference-Cited by-同舟云学术

Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein

Published:2018-02-15 Issue:6 Volume:19 Page:591-595
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Ehlers Martin¹,Grad Jean-Noël²,Mittal Sumit³,Bier David⁴,Mertel Marcel¹,Ohl Ludwig²,Bartel Maria⁴⁵,Briels Jeroen⁴⁵,Heimann Marius¹,Ottmann Christian⁴⁵,Sanchez-Garcia Elsa³,Hoffmann Daniel²,Schmuck Carsten¹^ORCID

Affiliation:

1. Institute of Organic Chemistry; University of Duisburg-Essen (Germany); Universitätsstrasse 7 45141 Essen Germany

2. Department of Bioinformatics and Computational Biophysics; ZMB/Faculty of Biology; University of Duisburg-Essen; 45117 Essen Germany

3. Computational Biochemistry; University of Duisburg-Essen; Universitätsstrasse 3 45141 Essen Germany

4. Department of Chemistry; University of Duisburg-Essen; Universitätsstrasse 7 45141 Essen Germany

5. Department of Biomedical Engineering and; Institute for Complex Molecular Systems; Technische Universiteit Eindhoven; P. O. Box 513 5600 MB Eindhoven Netherlands

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference39 articles.

1. The 14-3-3 cancer connection

2. Modulators of Protein–Protein Interactions

3. A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface

4. 14-3-3 proteins in the nervous system

5. The 14-3-3 proteins in regulation of cellular metabolism

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