On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach-Reference-Cited by-同舟云学术

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach

Published:2017-02-23 Issue:7 Volume:18 Page:666-675
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Driant Thomas¹^ORCID,Nachon Florian²^ORCID,Ollivier Cyril¹^ORCID,Renard Pierre-Yves³^ORCID,Derat Etienne¹^ORCID

Affiliation:

1. Sorbonne Universités; UPMC UNIV Paris 06; Institut Parisien de Chimie Moléculaire; UMR CNRS 8232; Case 229 4 Place Jussieu 75252 Paris Cedex 05 France

2. Département de Toxicologie et Risques Chimiques; Institut de Recherche Biomédicale des Armées; 1 Place Général Valérie André 91223 Brétigny-sur-Orge Cédex France

3. Normandie Université; COBRA; UMR 6014 and FR 3038; Université Rouen-Normandie; INSA Rouen; CNRS; 1 rue Tesnière 76821 Mont-Saint-Aignan Cedex France

Funder

Direction Générale de l’Armement

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference58 articles.

1. Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

2. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

3. Structural insights into substrate traffic and inhibition in acetylcholinesterase

4. A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate

5. Substrate and Product Trafficking through the Active Center Gorge of Acetylcholinesterase Analyzed by Crystallography and Equilibrium Binding

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