Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency-Reference-Cited by-同舟云学术

Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency

Published:2018-04-27 Issue:10 Volume:19 Page:1049-1059
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Zhao Xiguang¹,Kedei Noemi²^ORCID,Michalowski Alexandra²,Lewin Nancy E.²,Keck Gary E.¹,Blumberg Peter M.²

Affiliation:

1. Department of Chemistry; University of Utah; 315 South 1400 East RM 2020 Salt Lake City Utah 84112 USA

2. Laboratory of Cancer Biology and Genetics; Center for Cancer Research; National Cancer Institute; Building 37 Room 4048 37 Convent Drive MSC4255 Bethesda MD 20892-4255 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference55 articles.

1. Isolation and structure of bryostatin 1

2. The Chemistry and Biology of the Bryostatins: Potential PKC Inhibitors in Clinical Development

3. The Life and Death of Protein Kinase C

4. Protein kinase C and other diacylglycerol effectors in cancer

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