Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Author:

Judge Russell A.1,Vasudevan Anil1,Scott Victoria E.1,Simler Gricelda H.2,Pratt Steve D.1,Namovic Marian T.1,Putman C. Brent1,Aguirre Ana1,Stoll Vincent S.1,Mamo Mulugeta13,Swann Steven I.14,Cassar Steven C.1,Faltynek Connie R.1,Kage Karen L.15,Boyce-Rustay Janel M.16,Hobson Adrian D.2ORCID

Affiliation:

1. AbbVie, Inc.; 1 North Waukegan Road North Chicago IL 60064 USA

2. AbbVie Bioresearch Center; 100 Research Drive Worcester MA 01605 USA

3. Current address: Novartis Institute for Biomedical Research; 4560 Horton Street Emeryville CA 94608 USA

4. Current address: Takeda Pharmaceuticals; 10410 Science Center Drive San Diego CA 92121 USA

5. Current address: Altor Bioscience; 2810 North Commerce Parkway Miramar FL 33025 USA

6. Current address: Genentech; 1 DNA Way South San Francisco CA 94080 USA

Funder

AbbVie

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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