Epoxomicin and Eponemycin Biosynthesis Involvesgem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme-Reference-Cited by-同舟云学术

Epoxomicin and Eponemycin Biosynthesis Involvesgem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme

Published:2016-02-25 Issue:9 Volume:17 Page:792-798
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Zettler Judith¹²,Zubeil Florian³,Kulik Andreas⁴,Grond Stephanie³,Kaysser Leonard¹²

Affiliation:

1. Pharmaceutical Biology; University of Tübingen; Auf der Morgenstelle 8 72076 Tübingen Germany

2. German Centre for Infection Research (DZIF), partner site Tübingen; Auf der Morgenstelle 8 72076 Tübingen Germany

3. Institute of Organic Chemistry; University of Tübingen; Auf der Morgenstelle 18 72076 Tübingen Germany

4. Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT); Microbiology/Biotechnology; University of Tübingen; Auf der Morgenstelle 28 72076 Tübingen Germany

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201500567/fullpdf

Reference30 articles.

1. Electrophilic natural products and their biological targets

2. Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of α‘,β‘-Epoxyketone Proteasome Inhibitors

3. Epoxomicin, a new antitumor agent of microbial origin.

4. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency

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