The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Author:

Barini Erica1,Miccoli Ageo2,Tinarelli Federico3,Mulholland Katie1,Kadri Hachemi2,Khanim Farhat4,Stojanovski Laste5,Read Kevin D.5,Burness Kerry6,Blow Julian J.3,Mehellou Youcef2ORCID,Muqit Miratul M. K.17

Affiliation:

1. MRC Protein Phosphorylation and Ubiquitylation Unit; University of Dundee; Dow Street Dundee DD1 5EH UK

2. School of Pharmacy and Pharmaceutical Sciences; Cardiff University; King Edward VII Avenue Cardiff CF10 3NB UK

3. Centre for Gene Regulation and Expression; University of Dundee; Dow Street Dundee DD1 5EH UK

4. School of Biosciences; University of Birmingham; Edgbaston Birmingham B15 2TT UK

5. Drug Discovery Unit; University of Dundee; Dow Street Dundee DD1 5EH UK

6. MRC PPU Reagents and Services; University of Dundee; Dow Street Dundee DD1 5EH UK

7. School of Medicine; University of Dundee; Dow Street Dundee DD1 9SY UK

Funder

Wellcome Trust

Medical Research Council

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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