5-Hydroxymethyl-2′-Deoxyuridine Residues in the Thrombin Binding Aptamer: Investigating Anticoagulant Activity by Making a Tiny Chemical Modification-Reference-Cited by-同舟云学术

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5-Hydroxymethyl-2′-Deoxyuridine Residues in the Thrombin Binding Aptamer: Investigating Anticoagulant Activity by Making a Tiny Chemical Modification

Published:2014-09-11 Issue:16 Volume:15 Page:2427-2434
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Virgilio Antonella,Petraccone Luigi,Scuotto Maria,Vellecco Valentina,Bucci Mariarosaria,Mayol Luciano,Varra Michela,Esposito Veronica,Galeone Aldo

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference49 articles.

1. Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

2. Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

3. Direct thrombin inhibitors – a survey of recent developments

4. Engineering Aptamers for Biomedical Applications: Part I

5. Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair

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1. Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter;Nucleic Acids Research;2024-09-01

2. Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy;Cell Biochemistry and Biophysics;2024-06-25

3. Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide;Nucleic Acids Research;2023-07-28

4. A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers;Molecular Therapy - Nucleic Acids;2022-12

5. Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin;International Journal of Biological Macromolecules;2021-06

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