Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor-Reference-Cited by-同舟云学术

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

Published:2017-12-11 Issue:1 Volume:19 Page:58-65
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Marcozzi Alessio¹,Masini Tiziana²,Zhu Di²³,Pesce Diego¹,Illarionov Boris⁴,Fischer Markus⁴,Herrmann Andreas¹,Hirsch Anna K. H.²³⁵^ORCID

Affiliation:

1. Department Zernike Institute for Advanced Materials; University of Groningen; Nijenborgh 4 9747 AG Groningen The Netherlands

2. Stratingh Institute for Chemistry; University of Groningen; Nijenborgh 7 9747 AG Groningen The Netherlands

3. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Helmholtz Centre for Infection Research (HZI); Department of Drug Design and Optimization; Campus Building E8.1 66123 Saarbrücken Germany

4. Hamburg School of Food Science; Institute of Food Chemistry; Grindelallee 117 20146 Hamburg Germany

5. Department of Pharmacy; Medicinal Chemistry; Saarland University; Campus Building E8.1 66123 Saarbrücken Germany

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Dutch Ministry of Education, Culture and Science

European Research Council

the Netherlands Organisation for Scientific Research

Zernike Institute for Advanced Materials

Hans-Fischer-Gesellschaft

Chinese Scholarship Council

Helmholtz-Association

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference52 articles.

1. Global Tuberculosis Control: WHO report 2017 http://www.who.int/tb/publications/global_report/en/

2. World Malaria Report 2017 2017 http://www.who.int/malaria/publications/world-malaria-report-2017/en/

3. Extensive Drug Resistance in Malaria and Tuberculosis

4. Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

5. Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

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