Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation-Reference-Cited by-同舟云学术

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

Published:2015-10-26 Issue:17 Volume:16 Page:2507-2512
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Esposito Francesca¹,Tintori Cristina²,Martini Riccardo²,Christ Frauke³,Debyser Zeger³,Ferrarese Roberto⁴,Cabiddu Gianluigi¹,Corona Angela¹,Ceresola Elisa Rita⁴,Calcaterra Andrea⁵,Iovine Valentina⁵,Botta Bruno⁵,Clementi Massimo⁴,Canducci Filippo⁴⁶,Botta Maurizio²,Tramontano Enzo¹

Affiliation:

1. Department of Life and Environmental Sciences; University of Cagliari; Cittadella Universitaria di Monserrato SS 554 09042 Monserrato Cagliari Italy

2. Department of Biotechnologies; Chemical and Pharmacy; University of Siena; via Alcide de Gasperi 2 53100 Siena Italy

3. Laboratory for Molecular Virology and Gene Therapy; KU Leuven; 3000 Leuven Flanders Belgium

4. Laboratory of Virology; San Raffaele Hospital; IRCCS; via Olgettina 60 20132 Milano Italy

5. Dipartimento di Chimica e Tecnologie del Farmaco; Università di Roma “La Sapienza”; Piazzale Aldo Moro 5 00185 Roma Italy

6. Department of Department of Biotechnology and Life Sciences; University of Insubria; via Ravasi 2 21100 Varese Italy

Funder

European Union

Italian Ministero dell'Istruzione, dell'Università e della Ricerca, Prin 2010

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Past and Future. Current Drugs Targeting HIV-1 Integrase and Reverse Transcriptase-Associated Ribonuclease H Activity: Single and Dual Active Site Inhibitors

2. An Essential Interaction between Distinct Domains of HIV-1 Integrase Mediates Assembly of the Active Multimer

3. Relationship between the Oligomeric Status of HIV-1 Integrase on DNA and Enzymatic Activity

4. Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex

5. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

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