Affiliation:
1. Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran
2. Systematic Review and Meta‐analysis Expert Group (SRMEG) Universal Scientific Education and Research Network (USERN) Tehran Iran
3. Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran
4. Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran
Abstract
AbstractAn immunocompromised status has been associated with more odds of being infected with Mpox virus (MPXV) and progressing to severe disease. This aligns with the importance of immune competence for MPXV control and clearance. We and others have previously reviewed parallels between MPXV and other viruses belonging to the Poxviridae in affecting the immune system. This article reviews studies providing direct evidence of the MPXV‐immune interactions. The wide‐ranging effects of MPXV on the immune system, from stimulation to modulation to memory, are broadly categorised, followed by a detailing of these effects on the immune cells and molecules, including natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement.
Subject
Infectious Diseases,Virology
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8 articles.
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