Recessive mutations and chromosome deletions leading to cancer-Reference-Cited by-同舟云学术

Recessive mutations and chromosome deletions leading to cancer

Published:1989-04 Issue:4 Volume:76 Page:327-330
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Berne J¹,McColl I²,Adinolfi M¹

Affiliation:

1. Paediatric Research Unit, Division of Medical and Molecular Genetics, United Medical and Dental Schools of Guy's and St. Thomas' Hospitals, Guy's Campus, London Bridge, London SE1 9RT, UK

2. Department of Surgery, Division of Medical and Molecular Genetics, United Medical and Dental Schools of Guy's and St. Thomas' Hospitals, Guy's Campus, London Bridge, London SE1 9RT, UK

Abstract

Abstract This review examines the effect that a small chromosome deletion affecting a specific DNA sequence may have in producing a state of ‘hemizygosity’ for a gene or genes, and so triggering malignancy of the cells concerned. The association between such deletions and a variety of cancers will be considered and the implications for clinical practice will be outlined.

Funder

Spastics Society and the Paget Foundation

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/76/4/327/37058065/bjs1800760404.pdf

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3. The origin and development of human tumors studied with cell markers;Fialkow;N Engl J Med,1974

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