The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy-Reference-Cited by-同舟云学术

The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy

Published:1982-10 Issue:10 Volume:69 Page:595-597
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Greenway B¹²,Duke D¹²,Pym Barbara¹²,Iqbal M J¹²,Johnson P J¹²,Williams R¹²

Affiliation:

1. Liver Unit, King's College Hospital, London SE5

2. Department of Cancer Chemotherapy, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2

Abstract

Abstract The effect of hormone therapy on the growth of human non-endocrine pancreatic adenocarcinoma xenografts in nude mice was evaluated. The androgen testosterone stimulated tumour growth rate, whereas the anti-androgen cyproterone acetate significantly inhibited tumour growth rate compared with untreated controls. These findings provide further support for the suggestion that the growth and metabolism of pancreatic carcinoma may be dependent on the sex steroid hormones.

Funder

Cancer Research Campaign

Ned Foundation

Frances and Augustus Newman Foundation

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/69/10/595/36933931/bjs1800691013.pdf

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4. Establishment and characterisation of primary human pancreatic carcinoma in continuous cell culture and in nude mice;Grant;Br. J. Cancer,1979

5. Quantitative comparison of toxicity of anti-cancer agents in mouse, cat, hamster, monkey and man;Freireich;Cancer Chem. Rep.,1966

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