Affiliation:
1. Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN, UK
Abstract
Abstract
The impairment of healing in laparotomy wounds in rats with compensated oligaemia has been studied in two parallel investigations. Animals-bled 1 ml/100 g body weight (bled) were compared with unbled animals undergoing the same operation (control). Firstly, wounds were assessed after 22 days for strength of skin and muscle layers (11 control: 9 bled). Both layers were significantly weaker in bled animals; by 36 per cent for skin (P <0·02) and by 22 per cent for muscle (P = 0·02). Secondly, wound fibroblast function was assessed after 10 days by quantitative histology and autoradiography (30 control: 31 bled). There were no significant differences between the two groups for fibroblast density, replication ([3H]thymidine), or general protein synthesis ([3H]leucine). Bled animals had less dense collagen packing by 21 per cent (P <0·01), but 33 per cent more incorporation of ([3H]proline by fibroblasts (P <0·01) compared with control animals. The effect of compensated oligaemia on wound healing is more marked in skin than in muscle; it appears to be a specific increase in collagen turnover with the increase in reabsorption exceeding that in synthesis.
Publisher
Oxford University Press (OUP)
Cited by
7 articles.
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