Affiliation:
1. Academic Department of Surgery, The London Hospital Medical College, The Royal London Hospital, Whitechapel, London E1 1BB, UK
Abstract
Abstract
The rate of oxidation of butyrate, glutamine and glucose was investigated in terminal ileal mucosal biopsy samples from nine patients with ulcerative colitis undergoing restorative proctocolectomy and from 12 patients undergoing laparotomy for reasons other than ulcerative colitis. Substrate oxidation was assayed using a radiolabelled isotope technique. Butyrate was the preferred fuel substrate, followed by glutamine and then glucose (median (95 per cent confidence interval) 567 (262–894), 63 (35–123) and 81 (5·1–18) pmol μg−1 h−1 respectively; P <0·01, Mann-Whitney U test) in normal terminal ileal mucosa. The patients with ulcerative colitis had a significantly reduced rate of butyrate oxidation compared with the control group (194 (81–321) versus 567 (262–894) pmol μg−1 h−1, P < 0·05). Normal terminal ileal mucosa oxidized butyrate in greater quantities than glucose and glutamine. Ulcerative colitic terminal ileal mucosa exhibited an impaired rate of butyrate oxidation.
Publisher
Oxford University Press (OUP)
Cited by
54 articles.
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