Subtotal splenectomy in Gaucher's disease: Towards a definition of critical splenic mass

Author:

Zer M1,Freud E2

Affiliation:

1. Department of Pediatric Surgery, Beilinson Medical Center, Petah Tiqva, Israel

2. Sackler School of Medicine, Tel Aviv University, Israel

Abstract

Abstract Partial splenectomy is currently the favoured surgical approach for Gaucher's disease. Preservation of splenic tissue is indicated to prevent susceptibility to overwhelming postsplenectomy sepsis, to delay the massive deposition of glucocerebroside in the liver and bones, and to relieve symptoms of hypersplenism. Controversial issues and technical problems related to partial splenectomy for Gaucher's disease are discussed and a definition of critical splenic mass considered.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference35 articles.

1. Ninety-five percent splenectomy for massive splenomegaly: a new surgical approach;Fonkulsrud;J Pediatr Surg,1990

2. Partial splenectomy in Gaucher's disease;Rodgers;Ann Surg,1987

3. Methods of splenic preservation and their effect on clearance of pneumococcal bacteremia;Scher;Ann Surg,1985

4. Partial splenectomy in Gaucher disease;Govrin-Yehudain;Isr J Med Sci,1980

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