Early wound excision and skin grafting restores cellular immunity after severe burn trauma-Reference-Cited by-同舟云学术

Early wound excision and skin grafting restores cellular immunity after severe burn trauma

Published:1993-10 Issue:10 Volume:80 Page:1296-1298
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Cetinkale O¹,Ulualp K M²,Ayan F¹,Düren M²,Cizmeci O³,Pusane A¹

Affiliation:

1. Department of Emergency, Medical Faculty, Istanbul University, Istanbul, Turkey

2. General Surgery, Cerrahpasa Medical Faculty, Medical Faculty, Istanbul University, Istanbul, Turkey

3. Department of Plastic and Reconstructive Surgery, Medical Faculty, Istanbul University, Istanbul, Turkey

Abstract

Abstract Suppression of cellular immunity following thermal injury may contribute to the high incidence of postburn sepsis. Early excision and skin grafting may remove deleterious local wound factors and prevent immunosuppression. The effect on cellular immunity of early burn wound excision and skin grafting was investigated in an animal model using female Wistar rats. The development of immunosuppression shortly after burn injury was shown by popliteal lymph node assay and a 2,4-dinitrofluorobenzene skin reaction test. Excision and skin grafting 2 days after burn trauma restored parameters to normal. Burned tissue suppresses cellular immunity; this effect is preventable by early excision and skin grafting.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/80/10/1296/37106047/bjs1800801025.pdf

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