Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis

Author:

Patel R T1,Deen K I1,Youngs D1,Warwick J2,Keighley M R B1

Affiliation:

1. University Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK

2. Cancer Research Campaign Clinical Trials Unit, Queen Elizabeth Hospital, Birmingham, UK

Abstract

Abstract Levels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50–25 500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86·4 per cent with a specificity of 78·9 per cent and an overall correct classification rate of 82·9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72·7 per cent, specificity 57·9 per cent, correct classification rate 65·9 per cent). Levels of tumour necrosis factor α, IL-1β and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference26 articles.

1. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy;Parrillo;Ann Intern Med,1990

2. Treatment of Gramnegative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial;Ziegiei;N Engl J Med,1991

3. Cytokine appearance in human endotoxemia and primate bacteremia;Hesse;Surg Gynecol Obstet,1988

4. Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia coli;Creasey;Circ Shock,1991

5. Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia;Tracey;Nature,1987

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3