The occult osteomatous changes in the mandible in patients with familial polyposis coli

Author:

Utsunomiya Joji1,Nakamura Tadashi1

Affiliation:

1. Second Department of Surgery, Medical School, and Department of Radiology, Dental School, Tokyo Medical and Dental University

Abstract

Abstract Characteristic radio-opaque lesions were detected in the mandibular bone, most clearly on the panoramic X-ray, in 27 or 93·2 per cent out of 29 cases in 15 families with familial polyposis coli, including 21 cases without Gardner's stigmata, 7 cases with the incomplete syndrome and 1 with the complete syndrome. Only 3 out of 19 members of these families who were free from polyposis had radio-opaque jaw lesions. The cases with polyposis of other types also showed a negative result. The radiological diagnosis suggested that the lesions were of the character of endosteoma. Our observation is considered to be significant evidence in the understanding of the pathogenesis of Gardner's syndrome as well as a useful method for the early detection of carriers in the polyposis family.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference18 articles.

1. Intestinal polyposis associated with mucocutaneous melanin pigmentation (Peutz-Jeghers syndrome);Bartholomew;Gastroenterology,1957

2. Incidence of osteosclerotic areas in the mandible and maxilla;Boyne;J. Oral Surg.,1960

3. Bone abnormalities in Gardner's syndrome;Chang;Am. J. Roentgenol. Radium Ther. Nucl. Med.,1968

4. Gardner's syndrome and a new dental discovery;Fader;Oral Surg.,1962

5. Hereditary patterns for multiple osteomas in a family group;Gardner;Am. J. Hum. Genet.,1951

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