Affiliation:
1. Surgical Unit, Westminster Hospital, London SW1
Abstract
Abstract
Acute uraemia was induced in rats by performing a 70 per cent nephrectomy. Uraemia was shown to delay the healing of intestinal anastomoses and abdominal wounds in rats as judged by bursting strength tests. Cellular proliferation was depressed at wound edges but there was no reduction in the total amount of hydroxyproline present in the wounds. Fibroblast growth in tissue culture was affected by the addition both of uraemic plasma and of urea solution to the culture medium. The possible causes of these effects are discussed.
Publisher
Oxford University Press (OUP)
Reference32 articles.
1. Cytotoxicity of sera from healthy patients and patients with cancer;Arpels;Int. J. Cancer,1969
2. Catabolism of free hydroxyproline in chronic uraemia;Avioli;Am. J. Physiol.,1969
3. Observations on the surgical care of patients with post-traumatic renal insufficiency;Balch;Surg. Gynecol. Obstet.,1955
4. Acute tubular necrosis;Bluemle;Arch. Intern. Med.,1959
5. The effects of uraemia upon the survival of skin homografts;Burwell;Br. J. Surg.,1962
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